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Scientific interests

Bioinorganic chemistry of membrane transporter proteins, metal ion homeostasis in human pathogens, impact of metals on bacterial protein structure and function, thermodynamics and solution structure (NMR) of metal-biomolecule complexes, Mycobacterium tuberculosis pathogenicity, protein bioengineering.

 

 

Education

2014 - PhD in Inorganic Chemistry, University of Wrocław, Faculty of Chemistry, Wrocław, Poland.

Advisor: Prof. Henryk Kozłowski

Specificity of interaction of Zn2+ and Ni2+ ions with ZIP proteins domains.

2008 - MSc in Biotechnology

Wrocław University of Technology, Department of Chemistry, Wrocław, Poland.

Advisor: Prof. Marek Langner

Lipid aggregates relaxation – analysis of naproxen sodium salt binding at lipid membranes employing

micro-calorimetric studies.
2008 - MSc in Molecular Photonics for bio- and nanotechnologies

Ecole Normale Supérieure de Cachan (ENS), Paris, France.

2023_Chemia_fot. Dominika Hull-077a.jpg

​Important Positions

2017 - Researcher, University of Wrocław, Faculty of Chemistry, Wrocław, Poland.

2015 - 2017 Marie Skłodowska-Curie Research Fellow, Horizon 2020, University of Warwick, UK.

Biochemical and biophysical characterization of aeruginosin and cyanopeptolin polyketide synthases systems.

Solid-stare NMR studies of interaction of curcumin with β-amyloid oligomers.

Summer 2007 - Swedish internships

1) Thermometric AB (TA Instruments) – manufacturer of high performance calorimeters, the successfully fulfilled project focused on vaccine adjuvants and their membrane permeability, Stockholm, Sweden.
2) Inovacia AB – R&D and pharmaceutical company, Stockholm, Sweden.

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Research grants/awards

  • SONATA13, National Science Centre, Poland: Understanding the interactions of zinc with metal-sensing transcriptional regulators from Mycobacterial ArsR-family, 20.04.2018-20.04.2021.

  • Marie Skłodowska-Curie Individual Fellowship, Horizon 2020, University of Warwick, United Kingdom, 09.2015-09.2017.

  • EMBO scholarship Solution ad solid-state NMR of paramagnetic molecules, CERM, Florence, Italy, 13-19.07.2014.

  • Fernando Pulidori Award for scientific achievements from the European Group of Thermodynamics of Metal Complexes, International Symposium on Metal Complexes, Pavia, Italy, 8-12.06.2014.

  • GRANT PLUS Scholarship for outstanding young scientists working on the border of science and industry, 1.09.2013-31.05.2014.

  • European Science Foundation Grant for the participation in the 5th European Conference on Chemistry for Life Sciences, Barcelona, Spain, 10-12.06.2013.

  • Polish Society of Chemistry Travel Grant for the participation in the 5th European Conference on Chemistry for Life Sciences, Barcelona, Spain, 10-12.06.2013.

  • European Cooperation in Science and Technology Youth Travel Grant for the participation in the COST Summer School held in Louvain-la-Neuve, 12-19.05.2013.

  • European Social Fund Scholarship for Young PhDs, Young scientists – the potential to increase the competitiveness of the University of Wrocław, 10.2012-02.2013.

  • European Social Fund scholarship for PhD students, Young scientists – the potential to increase the competitiveness of the University of Wrocław, 03-07.2012.

  • Young Scientist Scholarship for Scientific Excellence L. Hirszfeld Scholarship of the mayor of Wrocław, 2011/2012.

  • European Science Foundation Grant for the participation in the 4th European Conference on Chemistry for Life Sciences, Budapest, Hungary, 31.08-3.09.2011.

 

 

Important workshops and internships

  • CLATHROPROBES, 778245, Marie Skłodowska-Curie Actions, Research and Innovation Staff Exchange, H2020-MSCA-RISE-2017Taras Shevchenko University, Kiev, Ukraine.

  • Solid-state NMR 850 MHz Annual Symposium and Workshop, The Institute of Advanced Study, University of Warwick Science Park, Warwick, UK.

  • EMBO Workshop, Solution ad solid-state NMR of paramagnetic molecules, CERM, Florence, Italy.

  • Chemistry of Metals in Biological Systems COST Workshop, Louvain-la-Neuve, Belgium.

  • NMR Internship at the University of Siena, Italy, advisor: Dr Daniela Valensin.

  • Institut de Recherches sur la Catalyse et l’Environnment de Lyon and Microcal, calorimetric workshop, Lion, France.

 

 

Selected Conferences

5-8.09.2018

XIV International Symposium on Inorganic Biochemistry, Co(II) and Zn(II) peptide complexes of Candida albicans zinc transport system, Wrocław, Poland.

15-19.07.2018

11th International Biometals Symposium, wygłoszony referat: Is Co(II) a good spectroscopic probe for Zn(II) ions in bioinorganic chemistry studies of metal transport proteins from human pathogens? Ottawa, Canada.

26-31.03.2017

58th Experimental Nuclear Magnetic Resonance Conference, Insights into the Specific Interaction of Alzheimer’s β-amyloid Toxic Oligomers with 13C Carbonyl-labelled Curcumin, Pacific Grove, California, USA.

22-24.03.2017

Directing Biosynthesis V, Investigating the interaction between halogenases and peptidyl carrier proteins involved in aeruginosin and cyanopeptolin biosynthesis, Warwick, UK.

8-12.06.2014

International Symposium on Metal Complexes, The specificity of Zn2+, Ni2+, Cd2+, Cu2+ and Bi3+ ions interactions with the unstructured domains of ZIP transporters (Fernando Pulidori Award), Pavia, Italy.
22-23.03.2014

VI Interdisciplinary Conference for PhD Students TYGIEL 2014, Zinc complexes with extracellular loop of IRT1 protein, Lublin, Poland.

XII International Symposium on Inorganic Biochemistry, The metal complexes with unstructured domains of ZIP transporters, Wrocław, Poland.

28.08-1.09.2013

5th European Conference on Chemistry for Life Sciences (5ECCLS), IRT1 Metal Transporter and Zinc. What is the Impact of Glu Residues on Metal Complex Stability?, Barcelona, Spain.

10-12.06.2013

11th European Biological Inorganic Chemistry Conference (EUROBIC11), The importance of cysteine in metal complexes of ZIP13 zinc transporter, Granada, Spain.

23-30.09.2008

4th Wrocław-Prague Seminar on Biophysics of Lipids, Studies on naproxen binding at lipid membranes, Analysis of naproxen sodium salt binding at lipid membranes, Wrocław, Poland.

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Selected published papers (cited over 520 times, h-index = 15, https://orcid.org/0000-0002-5528-7200)

  • A. Rola, R. Wieczorek, H. Kozłowski, K. Krzywoszyńska, S. Potocki, Sometimes less is more—the impact of the number of His residues on the stability of Zn(ii)–SmtB and BigR4 α-5 domain complexes, Dalton Transactions, 2021, 50, 12118.

  • K. Krzywoszyńska, J. Świątek-Kozłowska, S. Potocki, M. Ostrowska, H. Kozłowski, Triplet of cysteines – coordinational riddle?, Journal of Inorganic Biochemistry, 2020, 204, 110957.

  • V. Kovalska, M. Kuperman, Y. Losytskyy, S. Vakarov, S. Potocki, S. Yarmoluk, Y. Voloshin, O. Varzatskii, E. Gumienna-Kontecka, Induced CD of iron(II) clathrochelates: sensing of the structural and conformational alterations of serum albumins, Metallomics, 2019, 11, 338. ​

  • S. Potocki, P. Delgado, D. Dudek, A. Janicka-Kłos, H. Kozłowski, M. Rowińska-Żyrek, Pneumococcal HxxHxH triad - Copper(II) interactions - How important is the 'x'?, Inorganica Chimica Acta, 2019, 488, 255. ​

  • A. Miller, D. Dudek, S. Potocki, A. H. Czapor-Irzabek, H. Kozłowski, M. Rowińska-Żyrek, Pneumococcal histidine triads – involved not only in Zn2+, but also Ni2+ binding?, Metallomics, 10/2018, 1631. 

  • M. Remelli, D. Brasili, R. Guerrini, F. Pontecchiani, S. Potocki, M. Rowińska-Żyrek, J. Wątły, H. Kozłowski, Zn(II) and Ni(II) complexes with poly-histidyl peptides derived from a snake venom, Inorganica Chimica Acta, 01/2018, 472.

  • J. Wątły, S. Potocki, M. Rowińska-Żyrek, Zinc Homeostasis at the Bacteria/Host Interface - From Coordination Chemistry to Nutritional Immunity, Chemistry - A European Journal, 11/2016, 22(45), 15992.

  • P. Kołkowska, A. Hecel, D. Kędzierska, M. Ostrowska, P. K. Walencik, J. Wątły, K. Zdyb, M. Spodzieja, S. Rodziewicz-Motowidło, S. Potocki, M. Łuczkowski, E. Gumienna-Kontecka, M. Rowińska-Żyrek, HENRYK - An endless source of metal coordination surprises, Journal of Inorganic Biochememistry, 02/2016, 163, 258.

  • M. Y. Losytskyy, V. B. Kovalska, O. A. Varzatskii, M. V. Kuperman, S. Potocki, E. Gumienna-Kontecka, A. P. Zhdanov, S. M. Yarmoluk, Y. Z. Voloshin, K. Y. Zhizhin, N. T. Kuznetsov, A. V. Elskaya, An interaction of the functionalizedcloso-borates with albumins: The protein fluorescence quenching and calorimetry study, Journal of Luminescence, 08/2015, 169(2016), 51.

  • P. Kolkowska, K. Krzywoszynska, S. Potocki, P. R. Chetana, M. Spodzieja, S. Rodziewicz-Motowidlo, H. Kozlowski, Specificity of the Zn2+, Cd2+ and Ni2+ ion binding sites in the loop domain of the HypA protein, Dalton Transactions, 04/2015, 44(21).

  • M. Luczkowski, R. De Ricco, M. Stachura, S. Potocki, L. Hemmingsen, D. Valensin D, Metal ion mediated transition from random coil to β-sheet and aggregation of Bri2-23, a natural inhibitor of Aβ aggregation, Metallomics, 03/2015, 7(3), 478.

  • F. Pontecchiani, E. Simonovsky, R. Wieczorek, N. Barbosa, M. Rowinska-Zyrek, S. Potocki, M. Remelli, Y. Miller, H. Kozlowski, The unusual binding mechanism of Cu(II) ions to the poly-histidil domain of a peptide found in the venom of an African viper, Dalton Transactions, 09/2014, 43(44):16680.

  • H. Kozlowski, P. Kolkowska, J. Watly, K. Krzywoszynska, S. Potocki, General aspects of metal toxicity, Current Medicinal Chemistry, 07/2014; 21(33), 3721.

  • S. Potocki, D. Valensin, H. Kozlowski, The specificity of interaction of Zn2+, Ni2+ and Cu2+ ions with the histidine-rich domain of TjZNT1 ZIP family transporter, Dalton Transactions, 05/2014; 43, 10215.

  • R. De Ricco, S. Potocki, H. Kozlowski, D. Valensin, NMR investigations of metal interactions with unstructured soluble protein domains, Coordination Chemistry Reviews, 06/2014; 269, 1.

  • M. A. Zoroddu, M. Peana, S. Medici, S. Potocki, H. Kozlowski, Ni(II) binding to 429-460 peptide fragment from human tool like receptor (hTLR4): a crucial role for nickel-induced contact allergy, Dalton Transctions, 03/2014; 43(7), 2764.

  • S. Potocki, D. Valensin, F. Camponeschi, H. Kozlowski, The extracellular loop of IRT1 ZIP protein - the chosen one for zinc? Journal of Inorganic Biochemistry, 10/2013; 127, 246.

  • H. Kozlowski, S. Potocki, M. Remelli, M. Rowinska-Zyrek, D. Valensin, Specific metal ion binding sites in unstructured regions of proteins, Coordination Chemistry Reviews, 10/2013; 257(19-20), 2625.

  • M. Rowinska-Zyrek, S. Potocki, D. Witkowska, D. Valensin, H. Kozlowski, The zinc-binding fragment of HypA from Helicobacter pylori: a tempting site also for nickel ions, Dalton Transactions, 01/2013; 42(17), 6012.

  • M. Rowinska-Zyrek, D. Witkowska, S. Potocki, M. Remelli, H. Kozlowski, His-rich sequences - is plagiarism from nature a good idea? New Journal of Chemistry, 01/2013; 37(1), 58.

  • S. Potocki, M. Rowinska-Zyrek, D. Witkowska, M. Pyrkosz, A. Szebesczyk, K. Krzywoszynska, H. Kozlowski, Metal transport and homeostasis within the human body: toxicity associated with transport abnormalities, Current Medicinal Chemistry, 03/2012; 19(17):2738.

  • K. Krzywoszynska, M. Rowinska-Zyrek, D. Witkowska, S. Potocki, M. Luczkowski, H. Kozlowski, Polythiol binding to biologically relevant metal ions, Dalton transactions, 07/2011; 40(40), 10434.

  • S. Potocki, M. Rowinska-Zyrek, D. Valensin, K. Krzywoszynska, D. Witkowska, M. Luczkowski, H. Kozlowski, Metal binding ability of cysteine-rich peptide domain of ZIP13 Zn2+ ions transporter, Inorganic Chemistry, 07/2011; 50(13), 6135.

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